… and it’s out! Our latest work on early B cell development is now published in Blood Advances!
This study was a great collaborative effort between the Rizzi and the Mirjam van der Burg labs!
We identify an acquired non-permissive bone marrow microenvironment as a key obstacle to B cell reconstitution after HSCT. In a unique twin setting of X-linked lymphoproliferative disease (XLP), we show that impaired stromal support, rather than HSC-intrinsic defects alone, can drive long-lasting defects in B lymphopoiesis despite full donor chimerism.
A huge thank you to all collaborators for the great teamwork and discussions throughout this project — and special kudos to Melanie de Gier and everyone involved!
The paper:
de Gier M, Korzhenevich J, Schmidt F, Janowska I, van Ostaijen-Ten Dam MM, Pico-Knijnenburg I, Cats D, Keller F, Hadlova P, Kunze M, Markfeld-Erol F, Mei H, Reising K, Bredius RG, Lankester AC, van der Burg M, Rizzi M.
Blood Adv. 2026 Jan 16:bloodadvances.2025015915. doi: 10.1182/bloodadvances.2025015915. Online ahead of print. PMID: 41544216