Publications

Selection of most important papers from our laboratory. For the complete list of publications please refer to
→ PubMed.

2024

Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis.

Thiel J, Schmidt FM, Lorenzetti R, Troilo A, Janowska I, Nießen L, Pfeiffer S, Staniek J, Benassini B, Bott MT, Korzhenevich J, Konstantinidis L, Burgbacher F, Dufner AK, Frede N, Voll RE, Stuchly J, Bakardjieva M, Kalina T, Smulski CR, Venhoff N, Rizzi M.

Ann Rheum Dis. 2024 Oct 21;83(11):1536-1548. doi: 10.1136/ard-2024-225587.PMID: 388512ref_j95 

Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells.

Staniek J, Kalina T, Andrieux G, Boerries M, Janowska I, Fuentes M, Díez P, Bakardjieva M, Stancikova J, Raabe J, Neumann J, Schwenk S, Arpesella L, Stuchly J, Benes V, García Valiente R, Fernández García J, Carsetti R, Piano Mortari E, Catala A, de la Calle O, Sogkas G, Neven B, Rieux-Laucat F, Magerus A, Neth O, Olbrich P, Voll RE, Alsina L, Allende LM, Gonzalez-Granado LI, Böhler C, Thiel J, Venhoff N, Lorenzetti R, Warnatz K, Unger S, Seidl M, Mielenz D, Schneider P, Ehl S, Rensing-Ehl A, Smulski CR, Rizzi M.

Sci Immunol. 2024 Jan 12;9(91):eadj5948. doi: 10.1126/sciimmunol.adj5948. Epub 2024 Jan 12. PMID: 38215192

Free-access reprint link: https://www.science.org/stoken/author-tokens/ST-1652/full

2023

Human and mouse early B cell development: So similar but so different.

Korzhenevich J, Janowska I, van der Burg M, Rizzi M.

Immunol Lett. 2023 Sep;261:1-12. doi: 10.1016/j.imlet.2023.07.004. Epub 2023 Jul 11. PMID: 37442242

IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.

Kaiser FMP, Janowska I, Menafra R, de Gier M, Korzhenevich J, Pico-Knijnenburg I, Khatri I, Schulz A, Kuijpers TW, Lankester AC, Konstantinidis L, Erlacher M, Kloet S, van Schouwenburg PA, Rizzi M, van der Burg M.

Blood. 2023 Sep 28;142(13):1113-1130. doi: 10.1182/blood.2023019721. PMID: 37369082

JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in an in-vitro B cell differentiation model and in patients with rheumatoid arthritis.

Frede N, Lorenzetti R, Hüppe JM, Janowska I, Troilo A, Schleyer MT, Venhoff AC, Voll RE, Thiel J, Venhoff N, Rizzi M.

Front Immunol. 2023 Jan 26;14:1087986. doi: 10.3389/fimmu.2023.1087986. eCollection 2023. PMID: 36776828

2022

High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection.

Jacobsen EM, Fabricius D, Class M, Topfstedt F, Lorenzetti R, Janowska I, Schmidt F, Staniek J, Zernickel M, Stamminger T, Dietz AN, Zellmer A, Hecht M, Rauch P, Blum C, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Heeg M, Mayer B, Seidel A, Groß R, Münch J, Kirchhoff F, Bode SFN, Strauss G, Renk H, Elling R, Stich M, Voll RE, Tönshof B, Franz AR, Henneke P, Debatin KM, Rizzi M, Janda A.

Nat Commun. 2022 Nov 28;13(1):7315. doi: 10.1038/s41467-022-35055-1. PMID: 36437276

Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoimmunity as a consequence of impaired immune reactions.

Minguet S, Nyström A, Kiritsi D, Rizzi M.

Eur J Immunol. 2022 Sep;52(9):1396-1405. doi: 10.1002/eji.202149529. Epub 2022 Apr 30. PMID: 35443081

2021

Rapid and stable mobilization of CD8⁺ T cells by SARS-CoV-2 mRNA vaccine.

Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M.

Nature. 2021 Sep;597(7875):268-273. doi: 10.1038/s41586-021-03841-4. Epub 2021 Jul 28. PMID: 34320609

Editorial: TNFR Superfamily Oligomerization and Signaling.

Micheau O, Rizzi M, Smulski CR.

Front Cell Dev Biol. 2021 Apr 20;9:682472. doi: 10.3389/fcell.2021.682472. eCollection 2021. PMID: 33959618

Agammaglobulinemia with normal B-cell numbers in a patient lacking Bob1.

Kury P, Staniek J, Wegehaupt O, Janowska I, Eckenweiler M, Korinthenberg R, Japaridze N, Pendziwiat M, Helbig I, Verhoeyen E, Jung J, Garcia de Oteyza AC, Proietti M, Phirtskhalaishvili T, Rtskhiladze I, Nielsen PJ, Ehl S, Speckmann C, Rizzi M.

J Allergy Clin Immunol. 2021 May;147(5):1977-1980. doi: 10.1016/j.jaci.2021.01.027. Epub 2021 Feb 9. PMID: 33571536

2020

Editorial: Application of Cytometry in Primary Immunodeficiencies.

Kalina T, Abraham RS, Rizzi M, van der Burg M.

Front Immunol. 2020 Mar 19;11:463. doi: 10.3389/fimmu.2020.00463. eCollection 2020. PMID: 32265921

Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency.

Troilo A, Wehr C, Janowska I, Venhoff N, Thiel J, Rawluk J, Frede N, Staniek J, Lorenzetti R, Schleyer MT, Herget GW, Konstantinidis L, Erlacher M, Proietti M, Camacho-Ordonez N, Voll RE, Grimbacher B, Warnatz K, Salzer U, Rizzi M.

Blood. 2020 Apr 23;135(17):1452-1457. doi: 10.1182/blood.2019003855. PMID: 32157302

2019

TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.

Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, Warnatz K, Seidl M, Venhoff N, Thiel J, Smulski CR, Rizzi M.

Front Immunol. 2019 Apr 30;10:951. doi: 10.3389/fimmu.2019.00951. eCollection 2019. PMID: 31114586

Abatacept modulates CD80 and CD86 expression and memory formation in human B-cells.

Lorenzetti R, Janowska I, Smulski CR, Frede N, Henneberger N, Walter L, Schleyer MT, Hüppe JM, Staniek J, Salzer U, Venhoff A, Troilo A, Voll RE, Venhoff N, Thiel J, Rizzi M.

J Autoimmun. 2019 Jul;101:145-152. doi: 10.1016/j.jaut.2019.04.016. Epub 2019 May 1. PMID: 31054942

2017

Impact of tofacitinib treatment on human B-cells in vitro and in vivo.

Rizzi M, Lorenzetti R, Fischer K, Staniek J, Janowska I, Troilo A, Strohmeier V, Erlacher M, Kunze M, Bannert B, Kyburz D, Voll RE, Venhoff N, Thiel J.

J Autoimmun. 2017 Feb;77:55-66. doi: 10.1016/j.jaut.2016.10.005. Epub 2016 Oct 26. PMID: 27793425

2016

Disturbed B-lymphocyte selection in autoimmune lymphoproliferative syndrome.

Janda A, Schwarz K, van der Burg M, Vach W, Ijspeert H, Lorenz MR, Elgizouli M, Pieper K, Fisch P, Hagel J, Lorenzetti R, Seidl M, Roesler J, Hauck F, Traggiai E, Speckmann C, Rensing-Ehl A, Ehl S, Eibel H, Rizzi M.

Blood. 2016 May 5;127(18):2193-202. doi: 10.1182/blood-2015-04-642488. Epub 2016 Feb 23. PMID: 26907631

2015

Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency.

Wehr C, Gennery AR, Lindemans C, Schulz A, Hoenig M, Marks R, Recher M, Gruhn B, Holbro A, Heijnen I, Meyer D, Grigoleit G, Einsele H, Baumann U, Witte T, Sykora KW, Goldacker S, Regairaz L, Aksoylar S, Ardeniz Ö, Zecca M, Zdziarski P, Meyts I, Matthes-Martin S, Imai K, Kamae C, Fielding A, Seneviratne S, Mahlaoui N, Slatter MA, Güngör T, Arkwright PD, van Montfrans J, Sullivan KE, Grimbacher B, Cant A, Peter HH, Finke J, Gaspar HB, Warnatz K, Rizzi M; Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiency.

J Allergy Clin Immunol. 2015 Apr;135(4):988-997.e6. doi: 10.1016/j.jaci.2014.11.029. Epub 2015 Jan 14. PMID: 25595268

2014

B cell biology: an overview.

Eibel H, Kraus H, Sic H, Kienzler AK, Rizzi M.

Curr Allergy Asthma Rep. 2014 May;14(5):434. doi: 10.1007/s11882-014-0434-8. PMID: 24633618

A feeder-free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow.

Kraus H, Kaiser S, Aumann K, Bönelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, Burger M, Pieper K, Sic H, Rolink A, Eibel H, Rizzi M.

J Immunol. 2014 Feb 1;192(3):1044-54. doi: 10.4049/jimmunol.1301815. Epub 2013 Dec 30. PMID: 24379121