The collaborative work between the Vincent Gies Lab, Anne-Sophie Korganow Lab and the RizziLab has been published in Nature Communication! We found the anti-phospholipid (APS) specific B cells, cloned them and characterized their antigen receptors. We found that APS specificity is already present in the naive compartment and fails to be eliminated during the germinal center reaction. Not only APS specific memory B cells show signs of affinity maturation and are found in the bone marrow plasma cell compartment! Large collaborative effort, a lot of great discussion and many, many analyzed clones! Kudos to Yannick Dieudonné and Raquel Lorenzetti for this great work! C’est magnifique!
The paper:
Dieudonné Y, Lorenzetti R, Rottura J, Janowska I, Frenger Q, Jacquel L, Vollmer O, Carbone F, Chengsong Z, Luka M, Depauw S, Wadier N, Giorgiutti S, Nespola B, Herb A, Voll RE, Guffroy A, Poindron V, Ménager M, Martin T, Soulas-Sprauel P, Rizzi M, Korganow AS, Gies V.
Nat Commun. 2024 Nov 15;15(1):9921. doi: 10.1038/s41467-024-54228-8.PMID: 39548093 Free PMC article.